Most people think acid reflux is caused by having too much stomach acid. That is wrong — and it is the reason so many tourists in Spain reach for antacids night after night without ever feeling better. The real issue is not how much acid your stomach makes. It is that acid is escaping upward into your oesophagus (the tube connecting your mouth to your stomach), where it was never meant to go. Understanding this changes how you treat it, and getting the right acid reflux treatment in Spain is simpler than you might expect.
What's Happening When Acid Reflux Strikes?
At the bottom of your oesophagus sits a ring of muscle called the lower oesophageal sphincter. When you swallow food, this muscle relaxes to let the food pass into your stomach, then tightens again to keep stomach contents — including hydrochloric acid — where they belong. Acid reflux happens when that muscle relaxes at the wrong time or does not close tightly enough, allowing acidic stomach contents to wash back up into the oesophagus.[1]
Your stomach is lined with a thick layer of mucus that protects it from its own acid. Your oesophagus has no such protection. When acid contacts the oesophageal lining, it causes irritation, inflammation, and that burning sensation you recognise as heartburn. If this happens occasionally — say, after a very large meal — that is normal acid reflux. If it happens twice a week or more, doctors classify it as gastro-oesophageal reflux disease, or GERD, which can cause real tissue damage over time.[2]
Several things can weaken or relax that sphincter muscle. Fatty and fried foods, alcohol, coffee, citrus, and chocolate are common dietary triggers. Lying down soon after eating removes gravity's help in keeping acid down. Excess weight increases pressure on the abdomen, pushing stomach contents upward. Smoking weakens the sphincter directly. Certain medications — including some painkillers, blood pressure drugs, and sedatives — can also relax it.[3]
Travel to Spain stacks multiple triggers at once. Your eating schedule shifts. You are trying richer foods — fried tapas, cured meats, late dinners with wine. You may be eating larger portions later in the evening than you would at home, then lying down in an unfamiliar bed an hour or two later. Add the dehydration from heat, the extra coffee to fight jet lag, and the disruption to your normal routine, and your oesophageal sphincter is under more stress than usual. If you already have a tendency toward reflux, a Spanish holiday can push you from occasional discomfort into nightly misery.
What Does Acid Reflux Feel Like — and When Should You Worry?
The most recognisable symptom is heartburn — a burning sensation that starts behind your breastbone and can rise up toward your throat. Despite the name, your heart is not involved. The burn comes from stomach acid irritating the delicate lining of your oesophagus. You might also notice regurgitation, which is the sensation of acid or partially digested food coming back up into your throat or mouth. It leaves a sour or bitter taste that can linger for hours.[1]
There are less obvious symptoms too. A persistent dry cough, especially at night, can be caused by tiny amounts of acid reaching the back of your throat and irritating your airways. Hoarseness or a sore throat in the morning — when you have not been sick — often points to nighttime reflux. Some people feel a lump in the throat that never quite goes away, or experience difficulty swallowing. These are all signs that acid is reaching areas it should not.[2]
A proton pump inhibitor like omeprazole reduces stomach acid production by up to 90% within five days. For most people, heartburn symptoms improve within 24 to 48 hours of the first dose.
The timing of your symptoms tells you a lot. Reflux that worsens after meals, when bending over, or when lying down at night follows a classic pattern. If you are waking up at 2 or 3 in the morning with a burning throat and a sour taste, that is almost certainly acid reaching your oesophagus while you sleep. Keeping track of when the discomfort hits will help you — and any doctor you consult — identify the right approach to treatment.
Which Medications Actually Work for Acid Reflux?
Acid reflux treatment in Spain follows the same evidence-based approach used across Europe. The goal is to reduce the amount of acid your stomach produces so the oesophagus has time to heal. Here are your main options, from most effective to most immediately available.
Omeprazole 20 mg
Omeprazole is the first-line treatment for GERD worldwide. It works by permanently disabling the proton pumps in your stomach lining — tiny molecular machines that produce hydrochloric acid. One daily capsule reduces acid production by up to 90%, allowing inflamed oesophageal tissue to heal. A standard two-to-four-week course resolves symptoms in the vast majority of patients.[3] In Spain, omeprazole technically requires a receta médica, though some pharmacists may sell small packs at their discretion. For a reliable, documented supply, a prescription is the surest route.
Esomeprazole (Nexium) 20 mg
Esomeprazole is a refined version of omeprazole. It delivers slightly more consistent acid suppression over a 24-hour period, which some studies show produces faster healing in patients with more severe oesophageal inflammation.[4] In practice, it works very similarly to omeprazole for most people, and your doctor may recommend it if you have tried omeprazole before without complete relief.
Famotidine 20 mg
Famotidine reduces acid production by blocking histamine receptors on the acid-producing cells in your stomach. It is less powerful than a PPI but works faster — often within 30 to 60 minutes — making it useful for breakthrough symptoms or milder reflux. It replaced ranitidine (Zantac), which was withdrawn from markets worldwide in 2020 due to a contamination concern.[5]
Antacids — Almax and Gaviscon
Antacids work by chemically neutralising stomach acid that has already been produced. Almax (almagate) is the most popular antacid in Spain and is very effective for quick relief. Gaviscon goes a step further — it forms a foamy raft on top of your stomach contents that physically blocks acid from rising into the oesophagus. Neither addresses the root cause of reflux, but both provide comfort within minutes while you wait for a PPI to take full effect.[6]
What Can a Spanish Pharmacy Sell You Without a Prescription?
Spanish pharmacies — farmacias — can help you more than you might expect, even without a prescription. Antacids like Almax and Gaviscon are available over the counter and are displayed prominently in most pharmacies. Gaviscon Forte, the stronger liquid suspension, is a particularly good option for nighttime reflux because its raft-forming action lasts several hours. You can also find bismuth-based products and digestive enzymes. If you tell the pharmacist you have acidez de estómago (stomach acidity) or reflujo (reflux), they will know exactly what to recommend. Expect to pay between €3 and €10 for most over-the-counter options. What the pharmacy cannot give you without a prescription is a proton pump inhibitor like omeprazole or esomeprazole in a proper treatment course — and those are the medications that actually stop acid production rather than just neutralising what has already been made.